Research and projectsGrant projects

Grant projects CT-based diagnosis of bronchogenic carcinoma in patients with a severe form of COPD

Coordinator Coordinator: Hejduk Karel

Duration Duration: 2015–2015

Development of a methodically correct way of multicentre monitoring and recording of CT examination results in a group of patients who met the criteria of a severe form of COPD.

De-identified data were collected into the registry Czech Multicentre Research Database of COPD, which had been previously developed in cooperation with the Czech Pneumological and Phthisiological Society, and which aims to monitor real mortality and morbidity rates in an unselected group of COPD patients, their declination of lung function and other parameters, including assessment of the patients’ condition over time. A module called “CT examination of chest” was implemented into the structure of this pre-existing project; the parametric structure of this module corresponds to a consensus made by the expert society.

A total number of 144 patients complying with inclusion and exclusion criteria (as specified below) were recruited and expert descriptions of their CT images of chest were obtained. Professional dialogue then led to the development of clinical guidelines guaranteed by the Czech Pneumological and Phthisiological Society.

Inclusion criteria:

  • Post BDT FEV1 was lower than or equal to 60%
  • Confirmed COPD diagnosis
  • Stable patients’ condition, i.e. at least eight weeks without exacerbation
  • Patients’ residence in the centre’s catchment area (corresponding district)
  • Patients’ consent

Exclusion criteria:

  • Bronchial asthma without COPD
  • Bronchiectasis without CHOPN
  • Cystic fibrosis
  • Terminal stage of a malignancy (death expected within 3 months)
  • End-stage COPD (death expected within 3 months)
  • Significant non-compliance of the patient
  • Significant movement disorder

Other important information:

CHOPN registry: epidemiological database of COPD patients in the Czech Republic