Research and projectsGrant projects

Grant projects Comparison of effectiveness between colon capsule endoscopy and standard colonoscopy in persons with a positive result of immunological faecal occult blood test

Duration Duration: 2016–2019

This multicentre multidisciplinary prospective study is focused on the examination of persons with a usual risk of colorectal cancer (CRC), i.e. asymptomatic individuals aged between 50 and 75.

Between 2016 and 2019, a total of 230 individuals with a positive result of semiquantitative immunological faecal occult blood test (QuikRead, Orion Diagnostica Oy, Finland) with a positivity limit (cut-off value) of 75 ng/ml will be included in the study. Each participant will be examined by second-generation colon capsule endoscopy, followed by conventional colonoscopy. The primary objective is to determine whether the negative predictive value (NPV) of colon capsule endoscopy is adequate in order for this method to become a “filtration” test, aiming to decrease the need for a subsequent conventional colonoscopy.

  • Expert guarantor: Štěpán Suchánek, MD, PhD
  • Funding: The project has been supported by the Ministry of Health of the Czech Republic within the programme “Programme for the Support Medical Applied Research in 2015–2022”. The project is registered with the identifier NV16-29614A.
  • Partners: three centres specialised in gastroenterology, cooperation with general practitioners (GPs)
  • Brief overview of results: you can find more detailed information – in Czech language only – in the VaVaI information system