Research and projectsGrant projects

Grant projects

NEUROMINER

Duration Duration: 2017–2020

Revealing hidden patterns in data from brain imaging.

Comparison of effectiveness between colon capsule endoscopy and standard colonoscopy in persons with a positive result of immunological faecal occult blood test

Duration Duration: 2016–2019

This multicentre multidisciplinary prospective study is focused on the examination of persons with a usual risk of colorectal cancer (CRC), i.e. asymptomatic individuals aged between 50 and 75.

Efficacy of new spectroscopic biomarkers for the detection of early-stage pancreatic cancer

Duration Duration: 2016–2019

Determining the efficacy of advanced spectroscopic methods for the detection of pancreatic cancer (PC) and diabetes mellitus associated with pancreatic cancer (DMPC).

Data basis for mapping and assessing follow-up care and palliative care in the Czech Republic

Duration Duration: 2016–2016

The aim of the National Data Basis for Palliative Care is to map and to describe the end of life and the way of dying in the Czech Republic, based on available data sources in the National Health Information System (NHIS).

Ensuring interoperability between the Czech registry of haemophilia patients and the international database WAPPS-Hemo in the area of pharmacokinetics

Duration Duration: 2016–2016

Adequate amount of data on “similar” patients (in terms of age, weight, treatment type and factor degradation rate) is needed in order to obtain high-quality pharmacokinetic outcomes. Due to the prevalence of haemophilia, this was hard to achieve in the Czech Republic only; data centralisation was therefore in the interest of both physicians and patients.

Heredity

Duration Duration: 2016–2017

Contracting authority Contracting authority: Ministry of Health of the Czech Republic

Registry of patients with hereditary gynaecological cancers, including breast cancer.

Interactive communication of myasthenia gravis patients with the MyReg registry

Duration Duration: 2016–2016

MyReg is a registry collecting data on patients with myasthenia gravis, a rare autoimmune neuromuscular disorder.

CT-based diagnosis of bronchogenic carcinoma in patients with a severe form of COPD

Duration Duration: 2015–2015

Development of a methodically correct way of multicentre monitoring and recording of CT examination results in a group of patients who met the criteria of a severe form of COPD.

Innovations and analyses of the registry on patients with haemophilia and other coagulation disorders

Duration Duration: 2015–2015

Collecting data on patients with congenital coagulation disorders, analysis of these data, presentation and publication of results, developing a tool for pharmacokinetic testing of patients as part of the CNHP registry.

Registry of patients with diabetic macular oedema (DMO) treated with anti-VEGF medicines

Duration Duration: 2014–2014

Contracting authority Contracting authority: Czech Society of Ophthalmology

The diagnosis of diabetic macular oedema (DMO) is a complication of diabetic retinopathy (ocular complication of diabetes). The project involved the development and running of an electronic database for the collection of data on patients treated with anti-VEGF medicines.

Computational framework for joint analysis of histopathology images and gene expression data (HIGEX)

Duration Duration: 2014–2016

Histopathology imaging, genomics and their applications in oncology.

Monitoring the occurrence of alpha-1 antitrypsin deficiency in patients with a severe form of COPD

Duration Duration: 2014–2014

Development of a methodically correct way of multicentre monitoring and recording of A1AT deficit examination results in a group of patients who met the criteria of a severe form of COPD.

Integrative development of a multimodal score for risk of relapse estimation of breast cancer patients

Duration Duration: 2013–2015

Development of a combined (image and genomic) prognostic score for breast cancer and methods for the analysis of histopathology images – either separately or in combination with molecular data.

Ensuring information support and quality assessment of cancer screening programmes in the Czech Republic

Duration Duration: 2013–2013

Cancer screening programmes can contribute significantly to decreasing the population burden of cancer. However, such programmes are only effective if they are properly organised. The aim of the project was to maintain and to develop further the system for data collection and for quality control of cancer screening programmes.

Advanced methods for recognition of MR brain images for computer aided diagnosis of neuropsychiatric disorders

Duration Duration: 2012–2015

Development of software usable in clinical practice for computer-aided diagnosis of neuropsychiatric disorders from MR images of brain.

Parametric monitoring of TME quality as a tool to reduce local recurrences after surgery for rectal cancer

Duration Duration: 2012–2015

The parametric monitoring was aimed to increase the quality of surgical treatment and, as a result, to decrease the number of local recurrences after rectal cancer surgeries.

Quality assessment of multimodality treatment of patients with liver metastases of colorectal cancer in the Czech Comprehensive Cancer Centres

Duration Duration: 2012–2015

Verifying the benefit of a multidisciplinary team-based approach in the comprehensive treatment of patients with liver metastases of colorectal cancer, evaluating the results in defined groups of patients according to selected parameters.

Targeted screening of colorectal cancer in patients with type 2 diabetes and in individuals at a high cardiovascular risk: multicentre prospective study

Duration Duration: 2012–2015

The project objectives were to verify the hypothesis that individuals with a higher cardiovascular risk and diabetic patients are at a higher risk of developing colorectal neoplasia, to identify and to select these individuals for colonoscopy, which should subsequently verify the hypothesis that targeted screening is effective in this group of patients, and finally to verify the feasibility, effectiveness and safety of targeted screening.

Comparison of effectiveness between colon capsule endoscopy and standard colonoscopy in the detection of polyps and colorectal carcinomas: multicentre, prospective, crossover study

Duration Duration: 2010–2014

Contracting authority Contracting authority: Czech Society of Gastroenterology

This multicentre prospective study was focused on the comparison of detection of polyps and carcinomas during colon capsule endoscopy compared to conventional colonoscopy in individuals with an average risk of colorectal cancer.

Optimisation of data mining from clinical registries of the Czech National Health Information System (NHIS)

Duration Duration: 2009–2010

Making extensive, extraordinarily valuable data from Czech health registries accessible to a wide range of users – not only for research and publications, but also as a background for economic planning and decision-making.

Research of methods for the standardisation of health care focused on the development of the National Set of Clinical Standards and Healthcare Indicators

Duration Duration: 2009–2010

The National Set of Clinical Standards and Healthcare Indicators was developed with the aim to create a nationwide and standardised tool for further improvements in healthcare quality, which would be based on scientifically established clinical recommendations, the effect of which can be measured using specific quality indicators.

Information technology in biomedical engineering

Duration Duration: 2009–2012

This four-year project supported a team of 18 best PhD students in biomedical applications of computers science at Brno University of Technology (BUT) and Masaryk University (MU).

Interaction between pulse pressure, pulse wave velocity, augmentation index, natriuretic peptides and echocardiography and their predictive value in acute heart failure

Duration Duration: 2009–2011

Prognosis establishment is a crucial point for the optimisation of acute heart failure (AHF) management. The aim of the project was to evaluate the most important non-invasive prognostic parameters and to create a model combining these parameters in order to identify patients at risk of an unfavourable development of the condition.

Modern pattern recognition methods for image data analysis in neuropsychiatric research

Duration Duration: 2009–2011

Development of an authorised software utilisable in clinical practice for the diagnosis of selected neuropsychiatric disorders based on data from magnetic resonance imaging (MRI).

Calling 911 in response to stroke: change in individual behaviour following a two-year education campaign & ways to enhance public awarenes

Duration Duration: 2008–2010

The aim of this project was to identify whether there was a change in response to stroke symptoms in the Czech Republic following the two-year media campaign as compared to previously collected data from 2005. The secondary goal was to identify the predictors of such change in response to stroke symptoms and what prompted people to call 911.

Fragment and quantitative profiling of cell free fetal nucleic acids from maternal plasma in pathological and physiological pregnancies

Duration Duration: 2008–2010

The project was mainly oriented on testing of correlation between quantity and quality (size) of free foetal NA in maternal plasma during pregnancy at pathologies and normal controls. Data from analysis of STR loci, SNPs and gonosomal sequences were evaluated.

Indicators of EMS efficiency according to NACE

Duration Duration: 2007–2010

Contracting authority Contracting authority: Ministry of Environment of the Czech Republic

Design of new indicators for efficiency monitoring of environmental management systems, as well as system reporting, assessing the relations among the environment, economy and society.

Proposal of communication framework with international environmental information systems

Duration Duration: 2005–2007

Contracting authority Contracting authority: Ministry of Environment of the Czech Republic

Research project for the Ministry of Environment of the Czech Republic.

INCHEMBIOL – Interactions among the chemicals, environment and biological systems and their consequences on the global, regional and local scales

Duration Duration: 2005–2011

The main objective of this project was a complex approach to the research of interactions among chemical compounds present in environmental compartments and their biological effects: study of the fate of mainly persistent chemical compounds in the environment, their effects on the environment and living organisms including humans.