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List of all projects Comparison of effectiveness between colon capsule endoscopy and standard colonoscopy in the detection of polyps and colorectal carcinomas: multicentre, prospective, crossover study

Coordinator Coordinator: Májek Ondřej

Duration Duration: 2010–2014

Contracting authority Contracting authority: Czech Society of Gastroenterology

This multicentre prospective study was focused on the comparison of detection of polyps and carcinomas during colon capsule endoscopy compared to conventional colonoscopy in individuals with an average risk of colorectal cancer.


Between 2010 and 2014, a total of 232 individuals were examined by colon capsule endoscopy, followed by conventional colonoscopy; the latter was performed without the knowledge of result of the preceding examination. Apart from the main indicators (polyps, carcinomas), sensitivity and specificity were observed in individual subgroups (according to lesion type and size): polyps sized <6mm, ≥6mm, ≥ 10mm; adenomas sized ≥6mm, ≥10mm; and advanced adenomas (≥10mm or showing a villous structure or severe dysplasia) of any size. Level of bowel preparation (evaluated in four predefined degrees) and patient tolerance of examination were also evaluated. One of the main study objectives was to clarify whether colon capsule endoscopy might be used in colorectal cancer screening in the population with a high prevalence of this disease.

Project objectives:

  • In the short term, the study aimed to compare the sensitivity and specificity of examination by colon capsule endoscopy in terms of detection of colorectal polyps and carcinomas compared to conventional colonoscopy (which is the commonly used technique in clinical practice) in individuals with an average risk of colorectal cancer (i.e., asymptomatic individuals aged over 50).
  • In the long term, the study aimed to clarify whether colon capsule endoscopy might in future be employed in colorectal cancer screening in the population with a high prevalence of this disease (effectiveness in the detection of colorectal neoplasia, acceptability by the target population, cost-utility analysis).

Other important information:

  • Expert guarantor: Stepan Suchanek, MD
  • Funding: The project was supported by the Ministry of Health of the Czech Republic within the programme “Departmental Programme of Research and Development – MH III from 2010 to 2015”. The project is registered with the identifier NT11524.
  • Partners: four Czech health care facilities with the most experience in small bowel capsule endoscopy as well as colon capsule endoscopy
  • Brief overview of results: you can find more detailed information – in Czech language only – in the VaVaI information system


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