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Coordinator Coordinator: Strenkov√° Jana

Project start Project start: 2014

Clinical registry of patients with idiopathic pulmonary fibrosis (IPF).


The EMPIRE project is an international, multicentre, observational, non-interventional registry of IPF patients in the Czech Republic and Central and Eastern Europe.

According to the American Thoracic Society (ATS) and the European Respiratory Society (ERS), the idiopathic pulmonary fibrosis is defined as a specific form of chronic fibrosing interstitial pneumonia which affects exclusively lung parenchyma. Key characteristics of the disease involve abnormal histological findings (usual interstitial pneumonia, UIP) on surgical lung biopsy, exclusion of all other causes of interstitial lung disease, restrictive pattern of lung function and/or restriction of gas exchange and radiologic (X-ray, HRCT) abnormalities and negative BAL examination. IPF is considered to be a relatively rare disease; however, most recent studies dealing with this topic suggest that the incidence might be significantly higher.

Primary objective of the project:

  • to estimate IPF incidence, prevalence and mortality in Central and Eastern Europe.

Secondary objective of the project:

  • to describe basic characteristics (e.g. age, gender, risk factors etc.) of patients with IPF.

Other important information:

  • Expert guarantor: Assoc. Prof. Martina Vasakova, M.D., Ph.D.
  • Partners: dozens of pulmonary centres in four Central European and East European countries (you can find more detailed information on the website of the EMPIRE project)
EMPIRE: clinical registry of patients with idiopathic pulmonary fibrosis (IPF)

URL URL: http://empire.registry.cz


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